A series of three new metal (II) complexes of Schiff base were synthesized from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio. They were characterized by elemental analysis and spectral techniques like IR, 1H NMR, electronic spectrum and mass spectrum. IR spectral data suggested that the tetradentate ligand has coordination to metal ions through azomethine nitrogen, glycosidic oxygen and two amine nitrogens. Electronic spectral measurement indicated square planar geometry of Ni and Zn-complexes and tetrahedral geometry of Cu-complex with diamagnetic behavior. Molar conductivity measurements revealed non-electrolyte nature of the complexes where metal ions have coordination through doubly negative charged anions of the Schiff base. The thermal behavior (TGA/DTA) of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. XRPD technique revealed monoclinic crystal systems for Ni- and Zn-complexes and hexagonal crystal system for Cu-complex. The possible geometries of the metal complexes with their bond length were optimized by MM2 calculations using CsChem3D Ultra-11 program package software. Antibacterial sensitivity of the ligand and its metal complexes were assayed in vitro against four bacterial pathogens viz. E. coli, B. subtilis, S. aureus and K. pneumonia by Kirby Bauer paper disc diffusion method and showed moderate to better potency.
| Published in | American Journal of Applied Chemistry (Volume 2, Issue 1) |
| DOI | 10.11648/j.ajac.20140201.15 |
| Page(s) | 19-26 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Antibiotics, Aminoglycoside, Streptomycin, Schiff Base, β-Lactam
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APA Style
Narendra Kumar Chaudhary, Parashuram Mishra. (2014). In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling. American Journal of Applied Chemistry, 2(1), 19-26. https://doi.org/10.11648/j.ajac.20140201.15
ACS Style
Narendra Kumar Chaudhary; Parashuram Mishra. In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling. Am. J. Appl. Chem. 2014, 2(1), 19-26. doi: 10.11648/j.ajac.20140201.15
AMA Style
Narendra Kumar Chaudhary, Parashuram Mishra. In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling. Am J Appl Chem. 2014;2(1):19-26. doi: 10.11648/j.ajac.20140201.15
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Download@article{10.11648/j.ajac.20140201.15,
author = {Narendra Kumar Chaudhary and Parashuram Mishra},
title = {In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling},
journal = {American Journal of Applied Chemistry},
volume = {2},
number = {1},
pages = {19-26},
doi = {10.11648/j.ajac.20140201.15},
url = {https://doi.org/10.11648/j.ajac.20140201.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20140201.15},
abstract = {A series of three new metal (II) complexes of Schiff base were synthesized from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio. They were characterized by elemental analysis and spectral techniques like IR, 1H NMR, electronic spectrum and mass spectrum. IR spectral data suggested that the tetradentate ligand has coordination to metal ions through azomethine nitrogen, glycosidic oxygen and two amine nitrogens. Electronic spectral measurement indicated square planar geometry of Ni and Zn-complexes and tetrahedral geometry of Cu-complex with diamagnetic behavior. Molar conductivity measurements revealed non-electrolyte nature of the complexes where metal ions have coordination through doubly negative charged anions of the Schiff base. The thermal behavior (TGA/DTA) of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. XRPD technique revealed monoclinic crystal systems for Ni- and Zn-complexes and hexagonal crystal system for Cu-complex. The possible geometries of the metal complexes with their bond length were optimized by MM2 calculations using CsChem3D Ultra-11 program package software. Antibacterial sensitivity of the ligand and its metal complexes were assayed in vitro against four bacterial pathogens viz. E. coli, B. subtilis, S. aureus and K. pneumonia by Kirby Bauer paper disc diffusion method and showed moderate to better potency.},
year = {2014}
}
TY - JOUR T1 - In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling AU - Narendra Kumar Chaudhary AU - Parashuram Mishra Y1 - 2014/03/30 PY - 2014 N1 - https://doi.org/10.11648/j.ajac.20140201.15 DO - 10.11648/j.ajac.20140201.15 T2 - American Journal of Applied Chemistry JF - American Journal of Applied Chemistry JO - American Journal of Applied Chemistry SP - 19 EP - 26 PB - Science Publishing Group SN - 2330-8745 UR - https://doi.org/10.11648/j.ajac.20140201.15 AB - A series of three new metal (II) complexes of Schiff base were synthesized from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio. They were characterized by elemental analysis and spectral techniques like IR, 1H NMR, electronic spectrum and mass spectrum. IR spectral data suggested that the tetradentate ligand has coordination to metal ions through azomethine nitrogen, glycosidic oxygen and two amine nitrogens. Electronic spectral measurement indicated square planar geometry of Ni and Zn-complexes and tetrahedral geometry of Cu-complex with diamagnetic behavior. Molar conductivity measurements revealed non-electrolyte nature of the complexes where metal ions have coordination through doubly negative charged anions of the Schiff base. The thermal behavior (TGA/DTA) of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. XRPD technique revealed monoclinic crystal systems for Ni- and Zn-complexes and hexagonal crystal system for Cu-complex. The possible geometries of the metal complexes with their bond length were optimized by MM2 calculations using CsChem3D Ultra-11 program package software. Antibacterial sensitivity of the ligand and its metal complexes were assayed in vitro against four bacterial pathogens viz. E. coli, B. subtilis, S. aureus and K. pneumonia by Kirby Bauer paper disc diffusion method and showed moderate to better potency. VL - 2 IS - 1 ER -
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