Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize

Mao Jia; Feng Yizhi; Qi Xiaoxue; Han Jifeng; Pan Jinju; Liang Lin; Liu Wei; Zuo Bojun

doi:doi:10.11648/j.sjc.20190704.11

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Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize

Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, Liang Lin, Liu Wei, Zuo Bojun

Published in Science Journal of Chemistry (Volume 7, Issue 4)

Received: 11 September 2019 Accepted: 7 October 2019 Published: 17 October 2019

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Abstract

A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C₁₈). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.

Published in	Science Journal of Chemistry (Volume 7, Issue 4)
DOI	10.11648/j.sjc.20190704.11
Page(s)	72-76
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Isoxaflutole, Metabolites, Maize, Method, Residues

References

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[4]	http://db.ffcr.or.jp/front/pesticide_detail?id=6700
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[6]	Lin C H, Lerch R N, Thurman E M, et al. Determination of isoxaflutole (balance) and its metabolites in water using solid phase extraction followed by high-performance liquid chromatography with ultraviolet or mass spectrometry [J]. Journal of Agricultural and Food Chemistry, 2002, 50 (2): 5816-5824.
[7]	Lin C H, Lerch R N, Thurman E M, et al. Improved HPLC-MS/ MS method for determination of isoxaflutole (balance) and its metabolites in soils and forage plants [J]. Journal of Agricultural and Food Chemistry, 2007, 55 (10): 3805-3815.
[8]	Rouchaud J, Neus O, Eelen H, et al. Siol metabolism of isoxaflutole in corn [J]. Archives of Environmental Contamination and Toxicology, 2002, 42 (3): 280-285.
[9]	Yang C Z, Wang C S, Cheng Y, et al. Determination of isoxaflutole and its metabolite residues in maize by HPLC-MS/MS [J]. Food Science, 2011, 32 (22): 280-284.
[10]	National Health and Family Planning Commission of the People's Republic of China, The Ministry of Agriculture of the People's Republic of China. National food safety standard-Maximum residue limits for pesticides in food [S]. Beijing: Standards Press of China, 2016.
[11]	Liu X G, Xu J, Li Y B, et al. Rapid residue analysis of four triazolopyrimidine herbicides in soil, water, and wheat by ultraperformance liquid chromatography coupled to tandem mass spectrometry [J]. Analytical and Bioanalytical Chemistry, 2011, 399 (7): 2539-2547.
[12]	Liu N, Dong F S, Xu J et al. Determination of Aminoglycoside Fungicide Validamycin A in Rice Plant by Quick, Easy, Cheap, Effective, Rugged, and Safe Approach Using Ultra High Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry [J]. Food Analytical Methods, (2016) 9: 1736-1744.
[13]	Chen X X, Dong F S, Xu J, et al. Enantioseparation and determination of isofenphos-methylenantiomers in wheat, corn, peanut and soil with Supercritical fluidchromatography/tandem mass spectrometric method [J]. Journal of Chromatography B, 1015–1016 (2016) 13–21.
[14]	Feng Y Z, Li Y Jin J, et al. Determination of LH-2010A residues in potato and soil [J]. Chinese Journal of Pesticide Science2017, 19 (6): 760-764.
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APA Style

Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, et al. (2019). Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Science Journal of Chemistry, 7(4), 72-76. https://doi.org/10.11648/j.sjc.20190704.11

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ACS Style

Mao Jia; Feng Yizhi; Qi Xiaoxue; Han Jifeng; Pan Jinju, et al. Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Sci. J. Chem. 2019, 7(4), 72-76. doi: 10.11648/j.sjc.20190704.11

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AMA Style

Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, et al. Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Sci J Chem. 2019;7(4):72-76. doi: 10.11648/j.sjc.20190704.11

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@article{10.11648/j.sjc.20190704.11,
  author = {Mao Jia and Feng Yizhi and Qi Xiaoxue and Han Jifeng and Pan Jinju and Liang Lin and Liu Wei and Zuo Bojun},
  title = {Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize},
  journal = {Science Journal of Chemistry},
  volume = {7},
  number = {4},
  pages = {72-76},
  doi = {10.11648/j.sjc.20190704.11},
  url = {https://doi.org/10.11648/j.sjc.20190704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190704.11},
  abstract = {A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.},
 year = {2019}
}

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TY  - JOUR
T1  - Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize
AU  - Mao Jia
AU  - Feng Yizhi
AU  - Qi Xiaoxue
AU  - Han Jifeng
AU  - Pan Jinju
AU  - Liang Lin
AU  - Liu Wei
AU  - Zuo Bojun
Y1  - 2019/10/17
PY  - 2019
N1  - https://doi.org/10.11648/j.sjc.20190704.11
DO  - 10.11648/j.sjc.20190704.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 72
EP  - 76
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20190704.11
AB  - A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.
VL  - 7
IS  - 4
ER  -

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Author Information

Mao Jia

Institute of Agriculture Environment and Resource, Yunnan Academy of Agricultural Sciences, Kunming, China
Feng Yizhi

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China
Qi Xiaoxue

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China
Han Jifeng

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China
Pan Jinju

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China
Liang Lin

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China
Liu Wei

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China
Zuo Bojun

Key Laboratory for Chemical Pesticide of Shandong Province, Shandong Academy of Pesticide Sciences, Jinan, China

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APA Style

Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, et al. (2019). Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Science Journal of Chemistry, 7(4), 72-76. https://doi.org/10.11648/j.sjc.20190704.11

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ACS Style

Mao Jia; Feng Yizhi; Qi Xiaoxue; Han Jifeng; Pan Jinju, et al. Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Sci. J. Chem. 2019, 7(4), 72-76. doi: 10.11648/j.sjc.20190704.11

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AMA Style

Mao Jia, Feng Yizhi, Qi Xiaoxue, Han Jifeng, Pan Jinju, et al. Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize. Sci J Chem. 2019;7(4):72-76. doi: 10.11648/j.sjc.20190704.11

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@article{10.11648/j.sjc.20190704.11,
  author = {Mao Jia and Feng Yizhi and Qi Xiaoxue and Han Jifeng and Pan Jinju and Liang Lin and Liu Wei and Zuo Bojun},
  title = {Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize},
  journal = {Science Journal of Chemistry},
  volume = {7},
  number = {4},
  pages = {72-76},
  doi = {10.11648/j.sjc.20190704.11},
  url = {https://doi.org/10.11648/j.sjc.20190704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20190704.11},
  abstract = {A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Method for Residues Analysis of Isoxaflutole and Its Metabolites in Maize
AU  - Mao Jia
AU  - Feng Yizhi
AU  - Qi Xiaoxue
AU  - Han Jifeng
AU  - Pan Jinju
AU  - Liang Lin
AU  - Liu Wei
AU  - Zuo Bojun
Y1  - 2019/10/17
PY  - 2019
N1  - https://doi.org/10.11648/j.sjc.20190704.11
DO  - 10.11648/j.sjc.20190704.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 72
EP  - 76
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20190704.11
AB  - A rapid and sensitive analytical method for the determination of isoxaflutole and diketonitrile (DKN) residues in maize was established based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile and purified with octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in negative mode was selected. The isoxaflutole and DKN residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of isoxaflutole and DKN were linear in the range of 0.005-0.5mg/L with correlation coefficients of more than 0.9922. When the addition level ranged from 0.01 to 0.1mg/kg the average recoveries of isoxaflutole and DKN in maize, green maize and straw were 95%-108%, and the relative standard deviation (RSD) ranged from 2% to 11%. The limit of quantitation (LOQ) were 0.01 mg/kg in different matrices. This method has many characteristics, such as simple, rapid and accurate, and can be adapted for the confirmation of isoxaflutole and DKN residues in maize samples.
VL  - 7
IS  - 4
ER  -

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