Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism

Hou Zhenjiang; Mu Zhaoxin; Zhang Jingyu; Fan Hong; Hou Jianzhang; Wang Hongsheng

doi:doi:10.11648/j.cmr.20170603.18

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Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang, Wang Hongsheng

Published in Clinical Medicine Research (Volume 6, Issue 3)

Received: 4 May 2017 Published: 4 May 2017

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Abstract

To investigate the correlation between hypothyroidism and subclinical hypothyroidism in serum thyroid hormones, blood lipid profile, blood lipid ratio and homocysteine, the authors calculated the ratio of blood lipid and carried on statistical analysis through measuring the level of serum thyroid hormones, blood lipid, homocysteine among 60 patients with hypothyroidism, 140 patients with subclinical hypothyroidism and 60 controls. As a result, firstly, the levels of serum TSH in hypothyroidism group and subclinical hypothyroidism group were significantly higher than those in the control group (P <0.001).The difference between the subclinical hypothyroidism group and the control group had statistical significance (P <0.05).What’s more, the patients, who were hypothyroidism, were significantly lower than those in the control group in the levels of serum FT3 and FT4. Moreover, compared with the hypothyroidism and subclinical hypothyroidism, on the one hand, the levels of serum FT3 and FT4 obviously decreased, on the other hand, the levels of serum TSH and Hcy were significantly increased (P <0.01). As to the correlation of thyroid hormones with blood lipid ratio and non-HDL-C, TC showed the highest correlation and the sequences were non-HDL-C, LDL-C and LCI. In the end, the authors came to the conclusion that the detection of serum TSH, blood lipid ratio and Hcy were of great value in the transformation from subclinical hypothyroidism to hypothyroidism and the prediction of hypothyroidism and the cause of cardiovascular diseases.

Published in	Clinical Medicine Research (Volume 6, Issue 3)
DOI	10.11648/j.cmr.20170603.18
Page(s)	106-110
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Hypothyroidism, Subclinical Hypothyroidism, Thyroid Hormone, Blood Lipid Ratio, Homocysteine

References

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APA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang, et al. (2017). Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism. Clinical Medicine Research, 6(3), 106-110. https://doi.org/10.11648/j.cmr.20170603.18

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ACS Style

Hou Zhenjiang; Mu Zhaoxin; Zhang Jingyu; Fan Hong; Hou Jianzhang, et al. Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism. Clin. Med. Res. 2017, 6(3), 106-110. doi: 10.11648/j.cmr.20170603.18

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AMA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang, et al. Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism. Clin Med Res. 2017;6(3):106-110. doi: 10.11648/j.cmr.20170603.18

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@article{10.11648/j.cmr.20170603.18,
  author = {Hou Zhenjiang and Mu Zhaoxin and Zhang Jingyu and Fan Hong and Hou Jianzhang and Wang Hongsheng},
  title = {Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {3},
  pages = {106-110},
  doi = {10.11648/j.cmr.20170603.18},
  url = {https://doi.org/10.11648/j.cmr.20170603.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170603.18},
  abstract = {To investigate the correlation between hypothyroidism and subclinical hypothyroidism in serum thyroid hormones, blood lipid profile, blood lipid ratio and homocysteine, the authors calculated the ratio of blood lipid and carried on statistical analysis through measuring the level of serum thyroid hormones, blood lipid, homocysteine among 60 patients with hypothyroidism, 140 patients with subclinical hypothyroidism and 60 controls. As a result, firstly, the levels of serum TSH in hypothyroidism group and subclinical hypothyroidism group were significantly higher than those in the control group (P <0.001).The difference between the subclinical hypothyroidism group and the control group had statistical significance (P <0.05).What’s more, the patients, who were hypothyroidism, were significantly lower than those in the control group in the levels of serum FT3 and FT4. Moreover, compared with the hypothyroidism and subclinical hypothyroidism, on the one hand, the levels of serum FT3 and FT4 obviously decreased, on the other hand, the levels of serum TSH and Hcy were significantly increased (P <0.01). As to the correlation of thyroid hormones with blood lipid ratio and non-HDL-C, TC showed the highest correlation and the sequences were non-HDL-C, LDL-C and LCI. In the end, the authors came to the conclusion that the detection of serum TSH, blood lipid ratio and Hcy were of great value in the transformation from subclinical hypothyroidism to hypothyroidism and the prediction of hypothyroidism and the cause of cardiovascular diseases.},
 year = {2017}
}

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TY  - JOUR
T1  - Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism
AU  - Hou Zhenjiang
AU  - Mu Zhaoxin
AU  - Zhang Jingyu
AU  - Fan Hong
AU  - Hou Jianzhang
AU  - Wang Hongsheng
Y1  - 2017/05/04
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170603.18
DO  - 10.11648/j.cmr.20170603.18
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 106
EP  - 110
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170603.18
AB  - To investigate the correlation between hypothyroidism and subclinical hypothyroidism in serum thyroid hormones, blood lipid profile, blood lipid ratio and homocysteine, the authors calculated the ratio of blood lipid and carried on statistical analysis through measuring the level of serum thyroid hormones, blood lipid, homocysteine among 60 patients with hypothyroidism, 140 patients with subclinical hypothyroidism and 60 controls. As a result, firstly, the levels of serum TSH in hypothyroidism group and subclinical hypothyroidism group were significantly higher than those in the control group (P <0.001).The difference between the subclinical hypothyroidism group and the control group had statistical significance (P <0.05).What’s more, the patients, who were hypothyroidism, were significantly lower than those in the control group in the levels of serum FT3 and FT4. Moreover, compared with the hypothyroidism and subclinical hypothyroidism, on the one hand, the levels of serum FT3 and FT4 obviously decreased, on the other hand, the levels of serum TSH and Hcy were significantly increased (P <0.01). As to the correlation of thyroid hormones with blood lipid ratio and non-HDL-C, TC showed the highest correlation and the sequences were non-HDL-C, LDL-C and LCI. In the end, the authors came to the conclusion that the detection of serum TSH, blood lipid ratio and Hcy were of great value in the transformation from subclinical hypothyroidism to hypothyroidism and the prediction of hypothyroidism and the cause of cardiovascular diseases.
VL  - 6
IS  - 3
ER  -

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Author Information

Hou Zhenjiang

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Mu Zhaoxin

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhang Jingyu

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Fan Hong

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Hou Jianzhang

Department of Surgery, Cangzhou People's Hospital, Cangzhou Medical College, Cangzhou, China
Wang Hongsheng

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

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APA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang, et al. (2017). Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism. Clinical Medicine Research, 6(3), 106-110. https://doi.org/10.11648/j.cmr.20170603.18

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ACS Style

Hou Zhenjiang; Mu Zhaoxin; Zhang Jingyu; Fan Hong; Hou Jianzhang, et al. Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism. Clin. Med. Res. 2017, 6(3), 106-110. doi: 10.11648/j.cmr.20170603.18

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AMA Style

Hou Zhenjiang, Mu Zhaoxin, Zhang Jingyu, Fan Hong, Hou Jianzhang, et al. Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism. Clin Med Res. 2017;6(3):106-110. doi: 10.11648/j.cmr.20170603.18

Copy | Download

@article{10.11648/j.cmr.20170603.18,
  author = {Hou Zhenjiang and Mu Zhaoxin and Zhang Jingyu and Fan Hong and Hou Jianzhang and Wang Hongsheng},
  title = {Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {3},
  pages = {106-110},
  doi = {10.11648/j.cmr.20170603.18},
  url = {https://doi.org/10.11648/j.cmr.20170603.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170603.18},
  abstract = {To investigate the correlation between hypothyroidism and subclinical hypothyroidism in serum thyroid hormones, blood lipid profile, blood lipid ratio and homocysteine, the authors calculated the ratio of blood lipid and carried on statistical analysis through measuring the level of serum thyroid hormones, blood lipid, homocysteine among 60 patients with hypothyroidism, 140 patients with subclinical hypothyroidism and 60 controls. As a result, firstly, the levels of serum TSH in hypothyroidism group and subclinical hypothyroidism group were significantly higher than those in the control group (P <0.001).The difference between the subclinical hypothyroidism group and the control group had statistical significance (P <0.05).What’s more, the patients, who were hypothyroidism, were significantly lower than those in the control group in the levels of serum FT3 and FT4. Moreover, compared with the hypothyroidism and subclinical hypothyroidism, on the one hand, the levels of serum FT3 and FT4 obviously decreased, on the other hand, the levels of serum TSH and Hcy were significantly increased (P <0.01). As to the correlation of thyroid hormones with blood lipid ratio and non-HDL-C, TC showed the highest correlation and the sequences were non-HDL-C, LDL-C and LCI. In the end, the authors came to the conclusion that the detection of serum TSH, blood lipid ratio and Hcy were of great value in the transformation from subclinical hypothyroidism to hypothyroidism and the prediction of hypothyroidism and the cause of cardiovascular diseases.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Correlation of Blood Lipid Profile, Blood Lipid Ratio and Homocysteine in Patients with Hypothyroidism
AU  - Hou Zhenjiang
AU  - Mu Zhaoxin
AU  - Zhang Jingyu
AU  - Fan Hong
AU  - Hou Jianzhang
AU  - Wang Hongsheng
Y1  - 2017/05/04
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170603.18
DO  - 10.11648/j.cmr.20170603.18
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 106
EP  - 110
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170603.18
AB  - To investigate the correlation between hypothyroidism and subclinical hypothyroidism in serum thyroid hormones, blood lipid profile, blood lipid ratio and homocysteine, the authors calculated the ratio of blood lipid and carried on statistical analysis through measuring the level of serum thyroid hormones, blood lipid, homocysteine among 60 patients with hypothyroidism, 140 patients with subclinical hypothyroidism and 60 controls. As a result, firstly, the levels of serum TSH in hypothyroidism group and subclinical hypothyroidism group were significantly higher than those in the control group (P <0.001).The difference between the subclinical hypothyroidism group and the control group had statistical significance (P <0.05).What’s more, the patients, who were hypothyroidism, were significantly lower than those in the control group in the levels of serum FT3 and FT4. Moreover, compared with the hypothyroidism and subclinical hypothyroidism, on the one hand, the levels of serum FT3 and FT4 obviously decreased, on the other hand, the levels of serum TSH and Hcy were significantly increased (P <0.01). As to the correlation of thyroid hormones with blood lipid ratio and non-HDL-C, TC showed the highest correlation and the sequences were non-HDL-C, LDL-C and LCI. In the end, the authors came to the conclusion that the detection of serum TSH, blood lipid ratio and Hcy were of great value in the transformation from subclinical hypothyroidism to hypothyroidism and the prediction of hypothyroidism and the cause of cardiovascular diseases.
VL  - 6
IS  - 3
ER  -

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