Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

Younes Abrouki; Abdelkader Anouzla; Hayat Loukili; Rabiaâ Lotfi; Ahmed Rayadh; Abdellah Bahlaoui; Saı̈d Sebti; Driss Zakarya; Mohamed Zahouily

doi:doi:10.11648/j.ajtas.20130203.16

Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, Abdellah Bahlaoui, Saı̈d Sebti, Driss Zakarya, Mohamed Zahouily

Published in American Journal of Theoretical and Applied Statistics (Volume 2, Issue 3)

Received: 29 May 2013 Published: 20 June 2013

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Abstract

The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.

Published in	American Journal of Theoretical and Applied Statistics (Volume 2, Issue 3)
DOI	10.11648/j.ajtas.20130203.16
Page(s)	81-86
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

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References

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[6]	Y. Abrouki, M. Zahouily, A. Rayadh, B. Bahlaouan, S. Sebti, A natural phosphate and doped-catalyzed Michael addition of mercaptans to α,β-unsaturated carbonyl compounds, Tet. Lett., 43, (2002), pp. 8951-8953.
[7]	M. Ceylan, M. B. Gürdere, H. Gezegen, Y. Budak, Potassium-tertiary butoxide-assisted Addition of thioglycolic acid to chalcone derivatives under solvent-free conditions, Synt. Commun., 40 (2010), pp. 2598-2606.
[8]	J. T. Li, Y. Cui, G. F. Chen, Z. L. Cheng, T. S. Li, Michael Addition Catalyzed by Potassium Hydroxide Under Ultrasound, Synthetic Comm., 33, (2003), pp. 353-359.
[9]	T. C. Wabnitz, J. B. Spencer, A general Brønsted Acid-Catalyzed Hetero-Michael Addition of Nitrogen, Oxygen, and Sulfur Nucleophiles, Org. Lett., 12, (2003), pp. 2141-2144.
[10]	Y. Riadi, R. Mamouni, Y. Abrouki, M. El Haddad, N. Saffaj, S. El Antri, S. Routier, G. Guillaumet, S. Lazar, Animal Bone Meal (ABM): A Novel Natural Catalyst for Thia-Michael Addition, Tet. Lett., 51, (2010), pp. 6715-6717.
[11]	M. Zahouily, Y. Abrouki, A. Rayadh, S. Sebti, H. Dhimane, and M. David, Fluorapatite: efficient catalyst for the Michael addition, Tet. Lett. 44, (2003), pp. 2463-2465.
[12]	Smahi, A. Solhy, H. El Badaoui, A. Amoukal, A. Tikad, M. Maizi, and S. Sebti, Potassium fluoride doped fluorapatite and hydroxyapatite as new catalysts in organic synthesis Appl. Catal. A. Gen., 250, (2003), pp. 151-159.
[13]	Anouzla, Y. Abrouki, S. Souabi, M. Safi, H. Rhbal, Colour and COD removal of disperse Dye solution by a novel Coagulant: Application of statistical Design for the optimization and Regression analysis, J. Hazard. Mater., 166 (2009), pp. 1302-1306.

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APA Style

Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, et al. (2013). Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. American Journal of Theoretical and Applied Statistics, 2(3), 81-86. https://doi.org/10.11648/j.ajtas.20130203.16

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ACS Style

Younes Abrouki; Abdelkader Anouzla; Hayat Loukili; Rabiaâ Lotfi; Ahmed Rayadh, et al. Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. Am. J. Theor. Appl. Stat. 2013, 2(3), 81-86. doi: 10.11648/j.ajtas.20130203.16

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AMA Style

Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, et al. Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. Am J Theor Appl Stat. 2013;2(3):81-86. doi: 10.11648/j.ajtas.20130203.16

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@article{10.11648/j.ajtas.20130203.16,
  author = {Younes Abrouki and Abdelkader Anouzla and Hayat Loukili and Rabiaâ Lotfi and Ahmed Rayadh and Abdellah Bahlaoui and Saı̈d Sebti and Driss Zakarya and Mohamed Zahouily},
  title = {Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride},
  journal = {American Journal of Theoretical and Applied Statistics},
  volume = {2},
  number = {3},
  pages = {81-86},
  doi = {10.11648/j.ajtas.20130203.16},
  url = {https://doi.org/10.11648/j.ajtas.20130203.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajtas.20130203.16},
  abstract = {The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.},
 year = {2013}
}

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TY  - JOUR
T1  - Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride
AU  - Younes Abrouki
AU  - Abdelkader Anouzla
AU  - Hayat Loukili
AU  - Rabiaâ Lotfi
AU  - Ahmed Rayadh
AU  - Abdellah Bahlaoui
AU  - Saı̈d Sebti
AU  - Driss Zakarya
AU  - Mohamed Zahouily
Y1  - 2013/06/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ajtas.20130203.16
DO  - 10.11648/j.ajtas.20130203.16
T2  - American Journal of Theoretical and Applied Statistics
JF  - American Journal of Theoretical and Applied Statistics
JO  - American Journal of Theoretical and Applied Statistics
SP  - 81
EP  - 86
PB  - Science Publishing Group
SN  - 2326-9006
UR  - https://doi.org/10.11648/j.ajtas.20130203.16
AB  - The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.
VL  - 2
IS  - 3
ER  -

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Author Information

Younes Abrouki

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Abdelkader Anouzla

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Hayat Loukili

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Rabiaâ Lotfi
Ahmed Rayadh

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Abdellah Bahlaoui

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Saı̈d Sebti
Driss Zakarya

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Mohamed Zahouily

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

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Plain Text BibTeX RIS

APA Style

Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, et al. (2013). Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. American Journal of Theoretical and Applied Statistics, 2(3), 81-86. https://doi.org/10.11648/j.ajtas.20130203.16

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ACS Style

Younes Abrouki; Abdelkader Anouzla; Hayat Loukili; Rabiaâ Lotfi; Ahmed Rayadh, et al. Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. Am. J. Theor. Appl. Stat. 2013, 2(3), 81-86. doi: 10.11648/j.ajtas.20130203.16

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AMA Style

Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, et al. Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. Am J Theor Appl Stat. 2013;2(3):81-86. doi: 10.11648/j.ajtas.20130203.16

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@article{10.11648/j.ajtas.20130203.16,
  author = {Younes Abrouki and Abdelkader Anouzla and Hayat Loukili and Rabiaâ Lotfi and Ahmed Rayadh and Abdellah Bahlaoui and Saı̈d Sebti and Driss Zakarya and Mohamed Zahouily},
  title = {Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride},
  journal = {American Journal of Theoretical and Applied Statistics},
  volume = {2},
  number = {3},
  pages = {81-86},
  doi = {10.11648/j.ajtas.20130203.16},
  url = {https://doi.org/10.11648/j.ajtas.20130203.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajtas.20130203.16},
  abstract = {The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride
AU  - Younes Abrouki
AU  - Abdelkader Anouzla
AU  - Hayat Loukili
AU  - Rabiaâ Lotfi
AU  - Ahmed Rayadh
AU  - Abdellah Bahlaoui
AU  - Saı̈d Sebti
AU  - Driss Zakarya
AU  - Mohamed Zahouily
Y1  - 2013/06/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ajtas.20130203.16
DO  - 10.11648/j.ajtas.20130203.16
T2  - American Journal of Theoretical and Applied Statistics
JF  - American Journal of Theoretical and Applied Statistics
JO  - American Journal of Theoretical and Applied Statistics
SP  - 81
EP  - 86
PB  - Science Publishing Group
SN  - 2326-9006
UR  - https://doi.org/10.11648/j.ajtas.20130203.16
AB  - The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.
VL  - 2
IS  - 3
ER  -

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