Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children

Yuan Xiaohong; Li Peng; Li Yuwei

doi:doi:10.11648/j.ajhr.20190706.11

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Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children

Yuan Xiaohong, Li Peng, Li Yuwei

Published in American Journal of Health Research (Volume 7, Issue 6)

Received: 13 November 2019 Accepted: 27 November 2019 Published: 6 December 2019

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Abstract

Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.

Published in	American Journal of Health Research (Volume 7, Issue 6)
DOI	10.11648/j.ajhr.20190706.11
Page(s)	100-103
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Influenza A, Influenza B, Influenza-like Illness, Blood Routine Test, Neutrophils to Lymphocytes Ratio

References

[1]	Lipsitch M, Riley S, Cauchemez S, et al. Managing and reducing uncertainty in an emerging influenza pandemic [J]. N Engl J Med, 2009, 361 (2): 112-115.
[2]	Li liming. Epidemiology [M]. 6th edition. Beijing: people's medical publishing house, 2007: 430-447.
[3]	He hui, liu jieduo, zhou yingchun, et al. ROC curve evaluation of AFU and AFF in the diagnosis of primary liver cancer. International journal of laboratory medicine, 2006, 27 (2E18).
[4]	Luo yi, li jiqiang, zheng danwen, et al. Etiology investigation and clinical characteristics of acute upper respiratory tract infection virus. Chinese journal of traditional Chinese medicine, 2010, 8 (17): 178-181.
[5]	Dai xiaoqiu, liu min, haishan kaderbai, et al. Symptom monitoring analysis of 63325 patients in fever clinic of Beijing, China. Journal of Peking University: medical edition, 2oii, 43 (3): 375-378
[6]	Chen jian, li yan-ting, wang ye, et al. Comparison between colloidal gold method and virus isolation and identification in the diagnosis of influenza. Shanghai journal of preventive medicine, 2008, 20 (12): 573-574.
[7]	zhou ying, yu ronghuan, yu ping. Analysis of influenza surveillance in a sentinel hospital in Shanghai from 2007 to 2009]. Shanghai journal of preventiv medicine, 2010, 22 (6): 293-296.
[8]	le yanhong, huang fengguang, gao shuping. Analysis of influenza and surveillance results in heyuan city from 2014 to 2016, Chinese tropical medicine, 2018, 18 (1): 80-83.
[9]	wang peng, Yang xiaobing, kong deguang, et al. Analysis of influenza surveillance results in wuhan from 2012 to 2017, modern preventive medicine, 2018, 44 (1): 141-144.
[10]	letomik. A study on the role of granulocytes carcinomabearing hosts-G/L ratio as a new host indicator. Nippon Gan Chiryo Gakkai Shi, 1990, 25 (25): 662-671.
[11]	Ou q, Yin k x, lu y f, et al. Epidemiological investigation and analysis of clinical characteristics of influenza a (Influenza A) in Shanghai, Chinese journal of infectious diseases, 2009, 27 (10): 603-605. (in Chinese with English abstract)
[12]	Liu x j, tan b b, han j, et al. Significance of immunosuppressive acid protein/neutrophil/lymphocyte ratio and serum c-reactive protein detection in diagnosis of acute appendicitis. Hebei medicine, 2008, 30 (11): 1660-1661. (in Chinese with English abstract)
[13]	Hao t p, liang f y, lu z q. clinical study on the ratio of neutrophils to lymphocytes in patients with coronary heart disease, 2009, 11 (11): 1546-1547. (in Chinese with English abstract)
[14]	Yu x e. the value of neutrophil/lymphocyte ratio in predicting the severity of acute pancreatitis. Journal of gastroenterology and hepatology, 2012, 21 (6): 574-577. (in Chinese with English abstract)
[15]	Kemal Y, Yucel I, Ekiz K, et al. Elevated serum neutrophil to lymphocyte and platelet to iymphocyte ratios could be useful in lung cancer diagnosis [J]. Asian Pac J Cancer Prev, 2014, 15 (6): 265.

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APA Style

Yuan Xiaohong, Li Peng, Li Yuwei. (2019). Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. American Journal of Health Research, 7(6), 100-103. https://doi.org/10.11648/j.ajhr.20190706.11

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ACS Style

Yuan Xiaohong; Li Peng; Li Yuwei. Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. Am. J. Health Res. 2019, 7(6), 100-103. doi: 10.11648/j.ajhr.20190706.11

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AMA Style

Yuan Xiaohong, Li Peng, Li Yuwei. Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. Am J Health Res. 2019;7(6):100-103. doi: 10.11648/j.ajhr.20190706.11

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@article{10.11648/j.ajhr.20190706.11,
  author = {Yuan Xiaohong and Li Peng and Li Yuwei},
  title = {Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children},
  journal = {American Journal of Health Research},
  volume = {7},
  number = {6},
  pages = {100-103},
  doi = {10.11648/j.ajhr.20190706.11},
  url = {https://doi.org/10.11648/j.ajhr.20190706.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20190706.11},
  abstract = {Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.},
 year = {2019}
}

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TY  - JOUR
T1  - Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children
AU  - Yuan Xiaohong
AU  - Li Peng
AU  - Li Yuwei
Y1  - 2019/12/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ajhr.20190706.11
DO  - 10.11648/j.ajhr.20190706.11
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 100
EP  - 103
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20190706.11
AB  - Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.
VL  - 7
IS  - 6
ER  -

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Author Information

Yuan Xiaohong

Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Li Peng

Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Li Yuwei

Department of Genetics, Northwest Hospital for Women and Children, Xi'an, China

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Plain Text BibTeX RIS

APA Style

Yuan Xiaohong, Li Peng, Li Yuwei. (2019). Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. American Journal of Health Research, 7(6), 100-103. https://doi.org/10.11648/j.ajhr.20190706.11

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ACS Style

Yuan Xiaohong; Li Peng; Li Yuwei. Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. Am. J. Health Res. 2019, 7(6), 100-103. doi: 10.11648/j.ajhr.20190706.11

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AMA Style

Yuan Xiaohong, Li Peng, Li Yuwei. Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children. Am J Health Res. 2019;7(6):100-103. doi: 10.11648/j.ajhr.20190706.11

Copy | Download

@article{10.11648/j.ajhr.20190706.11,
  author = {Yuan Xiaohong and Li Peng and Li Yuwei},
  title = {Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children},
  journal = {American Journal of Health Research},
  volume = {7},
  number = {6},
  pages = {100-103},
  doi = {10.11648/j.ajhr.20190706.11},
  url = {https://doi.org/10.11648/j.ajhr.20190706.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20190706.11},
  abstract = {Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Application of Neutrophil-lymphocyte Ratio in the Diagnosis of Influenza in Preschool Children
AU  - Yuan Xiaohong
AU  - Li Peng
AU  - Li Yuwei
Y1  - 2019/12/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ajhr.20190706.11
DO  - 10.11648/j.ajhr.20190706.11
T2  - American Journal of Health Research
JF  - American Journal of Health Research
JO  - American Journal of Health Research
SP  - 100
EP  - 103
PB  - Science Publishing Group
SN  - 2330-8796
UR  - https://doi.org/10.11648/j.ajhr.20190706.11
AB  - Objective: To analyze the prevalence of influenza A/B in preschool children and neutrophils to lymphocytes ratio (NLR) of influenza A/B positive patients and patients with influenza-like illness, in order to provide more ideas and basis for the prevention, diagnosis and treatment of influenza-like illness. Methods: Children who were not more than 6 years old, and screened for antigen of influenza viruses in the Second Affiliated Hospital of Xi'an Jiaotong University, were enrolled in this study from November 2017 to February 2018. The venous blood or finger tip blood of the participants were collected for blood routine test. SPSS 19.0 software was used to analyze data. Results: Totally 99 (26.19%) cases with positive influenza A were observed in 378 children with influenza-like illness, 44 (11.64%) cases with positive influenza B, and the 225 cases were not infected. There was significant difference on the value of NLR between patients with influenza A infection and children without infection (P<0.05). When NLR was 0.42, the sensitivity for the prognosis was 86.1%, the specificity was 93.2%, and the area under curve (AUC) was 0.594. Conclusion: NLR has certain clinical value for the diagnosis of Influenza influenza, and can be helpful to diagnose influenza A virus infection by influenza virus antigen screening.
VL  - 7
IS  - 6
ER  -

Copy | Download