Dyslipidaemia is a major risk factor of cardiovascular disease of patients under haemodialysis. Both increase and decrease of cholesterol levels are associated with higher cardiovascular mortality rate in haemodialysis patients. The objective of this study was to assess the lipid dysfunction among patients maintained under haemodialysis in two reference centres of haemodialysis in Cameroon. A descriptive comparative study was carried out in Nephrology Unit of the University Teaching Hospital of Yaoundé and the same Unit of the Douala General Hospital, Cameroon. A total of 160 subjects were studied: Of these, there were 80 patients under haemodialysis and 80 healthy controls. Body mass index (BMI) was measured according to WHO’s guidelines. Serum total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were assayed before and after haemodialysis session. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedwald’s equation. Their cardiovascular risk indices (TC / HDL-C) were also determined. Patients under haemodialysis had significantly lower BMI as compared with the healthy controls (p < 0.05). Total Cholesterol, LDL-C and HDL-C were considerably lower before and after haemodialysis compared with the healthy controls (p ˂ 0.05). A non-significant difference was found between Triglycerides before and after haemodialysis in contrast with the healthy controls (p > 0.05). The cardiovascular risk indices (TC / HDL-C) of the patients under haemodialysis were higher than those of the healthy control group. Patients under haemodialysis had quite low BMI, total Cholesterol, LDL-C and HDL-C depicting malnutrition leading to inflammation, accelerated atherosclerosis process and cardiovascular complications.
| Published in | American Journal of Biomedical and Life Sciences (Volume 5, Issue 4) |
| DOI | 10.11648/j.ajbls.20170504.11 |
| Page(s) | 63-68 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Total Cholesterol, Lipoproteins, BMI, Haemodialysis, Cardiovascular Disease
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APA Style
Cédric Gueguim, Lucien Etamé Soné, Henriette Thérèse Dimodi, Marie Patrice Halle, François Kaze Folefack, et al. (2017). Assessment of Lipid Dysfunction of Patients Under Haemodialysis in Cameroon. American Journal of Biomedical and Life Sciences, 5(4), 63-68. https://doi.org/10.11648/j.ajbls.20170504.11
ACS Style
Cédric Gueguim; Lucien Etamé Soné; Henriette Thérèse Dimodi; Marie Patrice Halle; François Kaze Folefack, et al. Assessment of Lipid Dysfunction of Patients Under Haemodialysis in Cameroon. Am. J. Biomed. Life Sci. 2017, 5(4), 63-68. doi: 10.11648/j.ajbls.20170504.11
AMA Style
Cédric Gueguim, Lucien Etamé Soné, Henriette Thérèse Dimodi, Marie Patrice Halle, François Kaze Folefack, et al. Assessment of Lipid Dysfunction of Patients Under Haemodialysis in Cameroon. Am J Biomed Life Sci. 2017;5(4):63-68. doi: 10.11648/j.ajbls.20170504.11
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Download@article{10.11648/j.ajbls.20170504.11,
author = {Cédric Gueguim and Lucien Etamé Soné and Henriette Thérèse Dimodi and Marie Patrice Halle and François Kaze Folefack and Constant Anatole Pieme and Nnanga Nga and Wilfred Mbacham},
title = {Assessment of Lipid Dysfunction of Patients Under Haemodialysis in Cameroon},
journal = {American Journal of Biomedical and Life Sciences},
volume = {5},
number = {4},
pages = {63-68},
doi = {10.11648/j.ajbls.20170504.11},
url = {https://doi.org/10.11648/j.ajbls.20170504.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20170504.11},
abstract = {Dyslipidaemia is a major risk factor of cardiovascular disease of patients under haemodialysis. Both increase and decrease of cholesterol levels are associated with higher cardiovascular mortality rate in haemodialysis patients. The objective of this study was to assess the lipid dysfunction among patients maintained under haemodialysis in two reference centres of haemodialysis in Cameroon. A descriptive comparative study was carried out in Nephrology Unit of the University Teaching Hospital of Yaoundé and the same Unit of the Douala General Hospital, Cameroon. A total of 160 subjects were studied: Of these, there were 80 patients under haemodialysis and 80 healthy controls. Body mass index (BMI) was measured according to WHO’s guidelines. Serum total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were assayed before and after haemodialysis session. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedwald’s equation. Their cardiovascular risk indices (TC / HDL-C) were also determined. Patients under haemodialysis had significantly lower BMI as compared with the healthy controls (p 0.05). The cardiovascular risk indices (TC / HDL-C) of the patients under haemodialysis were higher than those of the healthy control group. Patients under haemodialysis had quite low BMI, total Cholesterol, LDL-C and HDL-C depicting malnutrition leading to inflammation, accelerated atherosclerosis process and cardiovascular complications.},
year = {2017}
}
TY - JOUR T1 - Assessment of Lipid Dysfunction of Patients Under Haemodialysis in Cameroon AU - Cédric Gueguim AU - Lucien Etamé Soné AU - Henriette Thérèse Dimodi AU - Marie Patrice Halle AU - François Kaze Folefack AU - Constant Anatole Pieme AU - Nnanga Nga AU - Wilfred Mbacham Y1 - 2017/07/06 PY - 2017 N1 - https://doi.org/10.11648/j.ajbls.20170504.11 DO - 10.11648/j.ajbls.20170504.11 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 63 EP - 68 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20170504.11 AB - Dyslipidaemia is a major risk factor of cardiovascular disease of patients under haemodialysis. Both increase and decrease of cholesterol levels are associated with higher cardiovascular mortality rate in haemodialysis patients. The objective of this study was to assess the lipid dysfunction among patients maintained under haemodialysis in two reference centres of haemodialysis in Cameroon. A descriptive comparative study was carried out in Nephrology Unit of the University Teaching Hospital of Yaoundé and the same Unit of the Douala General Hospital, Cameroon. A total of 160 subjects were studied: Of these, there were 80 patients under haemodialysis and 80 healthy controls. Body mass index (BMI) was measured according to WHO’s guidelines. Serum total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were assayed before and after haemodialysis session. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedwald’s equation. Their cardiovascular risk indices (TC / HDL-C) were also determined. Patients under haemodialysis had significantly lower BMI as compared with the healthy controls (p 0.05). The cardiovascular risk indices (TC / HDL-C) of the patients under haemodialysis were higher than those of the healthy control group. Patients under haemodialysis had quite low BMI, total Cholesterol, LDL-C and HDL-C depicting malnutrition leading to inflammation, accelerated atherosclerosis process and cardiovascular complications. VL - 5 IS - 4 ER -
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