The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso.
| Published in | American Journal of BioScience (Volume 8, Issue 1) |
| DOI | 10.11648/j.ajbio.20200801.11 |
| Page(s) | 1-5 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Securidaca longepedunculata, Flavonoids, Phenolic Acids, β-hematin, Antiplasmodial
| [1] | Haldar, K.; Bhattacharjee, S.; Safeukui, I. Drug resistance in Plasmodium. Nat. Rev. Microbiol. 2018, 16, 156–170. |
| [2] | Mahmoudi, S.; Keshavarz, H. Malaria Vaccine Development: The Need for Novel Approaches: A Review Article. Iran J Parasitol 2018, 13, 1–10. |
| [3] | Soh, P. N.; Benoit-Vical, F. Are West African plants a source of future antimalarial drugs. J. Ethnopharmacol. 2007, 114, 130–140. |
| [4] | Adebayo, J. O.; Krettli, A. U. Potential antimalarial Nigerian plants: A review. J. Ethnopharmacol. 2011, 133, 289–302. |
| [5] | Balunas, M. J.; Kinghorn, A. D. Drug discovery from medicinal plants. Life Sci. 2005, 78, 431–441. |
| [6] | Nitie-Kang, F.; Onguéne, P. A.; Lifongo, L. L.; Ndom, J. C.; Sippl, W.; Mbaze, L. M. The potential of anti-malarial compounds derived from African medicinal plants, part II : a pharmacological evaluation of non-alkaloids and non-terpenoids. Malar. J. 2014, 13, 1–20. |
| [7] | Negi, A. S.; Gupta, A.; Hamid, A. A. Combating Malaria with Plant Molecules : A Brief Update. Curr. Med. Chem. 2014, 21, 458–500. |
| [8] | Mongalo, N. I.; Mcgaw, L. J.; Finnie, J..; Van Staden, J. Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology. J. Ethnopharmacol. 2015, 165, 215–226. |
| [9] | Bah, S.; Jäger, A. K.; Adsersen, A.; Diallo, D.; Paulsen, B. S. Antiplasmodial and GABA (A)-benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa. J. Ethnopharmacol. 2007, 110, 451–7. |
| [10] | Diallo, D.; Diakité, C.; Mounkoro, P. P.; Sangaré, D.; Graz, B.; Falquet, J.; And; Giani, S. La prise en charge du paludisme par les therapeutes traditionnels dans les aires de santé de Kendie (Bandiagara) et de Finkolo (SIkasso) au mali. Mali Med. Tome XXII N°4 2007, 1–8. |
| [11] | Karama, I.; Compaoré, M.; Traore, O.; Sanon, S.; Lagnika, L.; Kiendrebeogo, M. Comparative study of leaves and root bark from Securidaca longepedunculata Fresen (Polygalaceae): phytochemistry and antiplasmodial activity. Pharma Innov. J. 2018, 7, 178–184. |
| [12] | Akkawi, M.; Jaber, S.; Abu-remeleh, Q.; Engeu, O. P.; Lutgen, P. Medicinal & Aromatic Plants Investigations of Artemisia annua and Artemisia sieberi Water Extracts Inhibitory Effects on β -Hematin Formation. 2014, 3, 1–5. |
| [13] | Deharo, E.; Porto, P.; Gimenez, A.; Sauvain, M.; Jullian, V. A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds. Exp. Parasitol. 2002, 100, 252–256. |
| [14] | Makler, M.; Ries, J.; Williams, J.; Bancroft, E.; Piper, R.; Gibbins, B.; Nrichs, D. Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am. J. Trop. Med. Hyg. 1993, 48, 739–741. |
| [15] | Symonowicz, M.; Kolanek, M. Flavonoids and their properties to form chelate complexes. Biotechnol. Food Sci. 2012, 76, 35–41. |
| [16] | Sashidhara, K. V; Singh, S. P.; Vardan, S.; Srivastava, R. K.; Srivastava, K.; Saxena, J. K.; Puri, S. K. Isolation and identi fi cation of b -hematin inhibitors from Flacourtia indica as promising antiplasmodial agents. Eur. J. Med. Chem. 2013, 60, 497–502. |
| [17] | Manu, S.; Deshmukh, R.; Prasad, K. M. N.; Trivedi, V. Screening and Characterization of Antimalarial Heme Polymerase Inhibitors from Garlic Cloves. European J. Med. Plants 2013, 3, 474–484. |
| [18] | Alrawaiq, N. S.; Abdullah, A. A Review of Flavonoid Quercetin : Metabolism, Bioactivity and Antioxidant Properties. Int. J. Pharm Tech Res. 2014, 6, 933–941. |
| [19] | Coronado, L. M.; Nadovich, C. T.; Spadafora, C. Malaria Hemozoin: From target to toll. Biochim Biophys Acta 2014, 1840, 2032–2041. |
| [20] | Lehane, A. M.; Saliba, K. J. Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite. BMC Res. Notes 2008, 5, 1–5. |
| [21] | Vargas, S.; Ioset, K. N.; Hay, A.; Ioset, J.; Wittlin, S.; Hostettmann, K. Journal of Pharmaceutical and Biomedical Analysis Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation. J. Pharm. Biomed. Anal. 2011, 56, 880–886. |
| [22] | Nag, S.; Prasad, K. M. N.; Trivedi, V. Identification and screening of antimalarial phytochemical reservoir from northeastern Indian plants to develop PfRIO-2 kinase inhibitor. Eur. Food Res. Technol. 2012, 234, 905–911. |
| [23] | Kurosawa, Y. A. E.; Dorn, A.; Kitsuji-shirane, M.; Shimada, H.; Satoh, T.; Matile, H.; Hofheinz, W.; Masciadri, R.; Kansy, M.; Ridley, R. G. Hematin Polymerization Assay as a High-Throughput Screen for Identification of New Antimalarial Pharmacophores. Antimicrob. Agents Chemother. 2000, 44, 2638–2644. |
| [24] | Khasanah, U.; WidyaWarumyanti, A.; Hafid, A. F.; Tanjung, M. Antiplasmodial activity of isolated polyphenol from Alectryon serratus leaves against 3D7 Plasmodium falciparum. Pharmacognosy Res. 2017, 9, 57–60. |
| [25] | Xi, J.; Guo, R. Interactions between flavonoids and hemoglobin in lecithin liposomes. Int. J. Biol. Macromol. 2007, 40, 305–311. |
APA Style
Issa Karama, Moussa Compaoré, Abdoulaye Djandé, Orokia Traoré, Latifou Lagnika, et al. (2020). Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae). American Journal of BioScience, 8(1), 1-5. https://doi.org/10.11648/j.ajbio.20200801.11
ACS Style
Issa Karama; Moussa Compaoré; Abdoulaye Djandé; Orokia Traoré; Latifou Lagnika, et al. Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae). Am. J. BioScience 2020, 8(1), 1-5. doi: 10.11648/j.ajbio.20200801.11
AMA Style
Issa Karama, Moussa Compaoré, Abdoulaye Djandé, Orokia Traoré, Latifou Lagnika, et al. Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae). Am J BioScience. 2020;8(1):1-5. doi: 10.11648/j.ajbio.20200801.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajbio.20200801.11,
author = {Issa Karama and Moussa Compaoré and Abdoulaye Djandé and Orokia Traoré and Latifou Lagnika and Martin Kiendrebeogo},
title = {Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae)},
journal = {American Journal of BioScience},
volume = {8},
number = {1},
pages = {1-5},
doi = {10.11648/j.ajbio.20200801.11},
url = {https://doi.org/10.11648/j.ajbio.20200801.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20200801.11},
abstract = {The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso.},
year = {2020}
}
TY - JOUR T1 - Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae) AU - Issa Karama AU - Moussa Compaoré AU - Abdoulaye Djandé AU - Orokia Traoré AU - Latifou Lagnika AU - Martin Kiendrebeogo Y1 - 2020/02/28 PY - 2020 N1 - https://doi.org/10.11648/j.ajbio.20200801.11 DO - 10.11648/j.ajbio.20200801.11 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 1 EP - 5 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.20200801.11 AB - The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso. VL - 8 IS - 1 ER -
Email: