Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar

Monteomo Gnate François; Tehoua L.; Ouattara H.; Yapi A.

doi:doi:10.11648/j.ajbio.20140202.17

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Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar

Monteomo Gnate François, Tehoua L., Ouattara H., Yapi A.

Published in American Journal of BioScience (Volume 2, Issue 2)

Received: 20 February 2014 Accepted: 8 April 2014 Published: 10 April 2014

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Abstract

The barks of thunk of Sclerocarya birrea (ANARCADIACEA) and Khaya senegalensis (ANARCADIACEA) associated with the leaves of Heliotropium indicum (BORRAGINACEA) and Ocimum gratissimum (CESALPINIACEA) usually constitutes a traditional remedy use in Côte d’Ivoire for the treatment of diabetes. This remedy is use according administration a small dose to 35mg/kg. For that reason, each healing plant above was studied to estimate their real effect on the glycaemia of hyperglycemic rats the rats were submitted at oral load of glucose (4g/kg) after received only dose of plant extract. The result showed that, rats whose administrated the aqueous extract of Scleroracaryo birrea, Khaya senegalensis and the aqueous extract of Khaya senegalensis had significant antihypergliycemic effects respectively 30% and 20% (p<0,05 ; n= 8) after 2 hours. These reductions of blood glucose reached 40% and 26% at the 4 hour. The aqueous extract of Ocimum gratissimum didn’t show a significant effect on the glucose blood of the rats, the decrease was 4,5% (p<0,05; n= 8). Concerning the aqueous extract of Heliotropium indicum, we noticed no antihyperglycemic effect on the blood of the rats tested. The phytochemical analysis revealed the presence of alkaloids, coumarins and tannins to Sclerocarya birrea. Khaya senegalensis contained alkaloids and coumarins and polyphenols to Heliotropium indicum. The aqueous extract of Ocimum gratissimum contained flavonoid and tannins. Conclusion: The antihyperglycemic effect of the traditional preparation could be due of antidiabetic activities of Sclerocarya birrea and Khaya senegalensis. However, the aqueous of Heliotroppium indicum and Ocimum gratissimum hadn’t antidiabetic effect so, its can be considered as additives in this traditional preparation. Others detailed investigations are in progress to isolate active ingredient and to determine their mechanism.

Published in	American Journal of BioScience (Volume 2, Issue 2)
DOI	10.11648/j.ajbio.20140202.17
Page(s)	60-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Diabetes, Aqueous Extracts, Antihyperglycemic Effect, Rats Wistar

References

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[2]	Awah PK. Diabète et médecine traditionnelle en Afrique. Soins de santé, Diabetes Voice, 2006; 51, 3: 24-26
[3]	Aké AL. Abrégé de médecine et pharmacopée africaines : quelques plantes employées traditionnellement dans la couverture des soins de santé primaire. Edition NEI-CEDA ; 2012 ; 82- 86.
[4]	Breneton J. pharmacognosie. Phytochimie. Plantes médicinales. Paris, Lavoisier, 2002 ; 3,1095
[5]	Debuigue G. Larousse des plants qui guérissent. Librairie Larousse, 1984;5-6.
[6]	Diaine C. Cours de statistique 1ère année d’étude de pharmacie, 1990; 36-42.
[7]	Hmamouch M, Garras L, Lamnouar D, Begoumi M. Etude comparative de l’effet hypoglycémiant de zygophyllum cornutum, de Marrubium vulgate L, d’Artemisia herba-alba, d’olea europaea et du glibenclamide chez des rats soumis à une hyperglycémie provoquée. Rev. Méd.Pharm.Afr. 1995; 9, 2,39-47.
[8]	Keita A, Mariko E, Haidara TK. Etude de l'activité hypoglycémiante des feuilles de Sclerocarya birrea (A. Rich) Hochst. (anacardiaceae) Pharm. Méd. Trad. Afr.1998,10,16-25.
[9]	Kerharo J, Adam JC. La pharmacopée sénégalaise traditionnelle : plantes médicinales et tropicales. Paris, Ed Vigot et frères, 1974; 433-35.
[10]	Konkon NG, Adjoungoua AL, Manda P, Simaga D. Toxicological and phytochemical screening study of Mitragyna inermis willd O.Ktze Rubiacea, antidiabetic plant. J of Medecinaplants research. 2008 ; 2(10), 279- 284.
[11]	Lokrou A. Guide de prise en charge des diabétiques. Collection santé, Editions Universitaires de Côte d’Ivoire. 2008 ; 123-134.
[12]	Nemlin J, Brunel JF. Travaux pratiques de matière médicale, 3ème année, Paris, Masson, 1996; 39-43.
[13]	Oga ASS, Tebi A, Aka J, Adoueni KV, Malan LP, Lokrou A. Le diabète sucré diagnostiqué en Côte d’Ivoire : des particularités épidémiologiques. Med Trop, 2006 ; 66 : 241-248.
[14]	Ojewole JAO. Hypoglycemic effect of Sclerocarya birrea (A Rich) Hochst (Anacardiacea) stem bark aqueous extra in rats. Phytomed, 2003; 10(8): 675-81.
[15]	Weiss J, Taylor GR, Zimmermann F et al. Collection of body fluids. In: Krinke GJ.The laboratory rat, the handbook of experimental animal. Academic press.2000;25,p 485-495.

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Monteomo Gnate François, Tehoua L., Ouattara H., Yapi A. (2014). Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar. American Journal of BioScience, 2(2), 60-63. https://doi.org/10.11648/j.ajbio.20140202.17

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Monteomo Gnate François; Tehoua L.; Ouattara H.; Yapi A. Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar. Am. J. BioScience 2014, 2(2), 60-63. doi: 10.11648/j.ajbio.20140202.17

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Monteomo Gnate François, Tehoua L., Ouattara H., Yapi A. Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar. Am J BioScience. 2014;2(2):60-63. doi: 10.11648/j.ajbio.20140202.17

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@article{10.11648/j.ajbio.20140202.17,
  author = {Monteomo Gnate François and Tehoua L. and Ouattara H. and Yapi A.},
  title = {Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar},
  journal = {American Journal of BioScience},
  volume = {2},
  number = {2},
  pages = {60-63},
  doi = {10.11648/j.ajbio.20140202.17},
  url = {https://doi.org/10.11648/j.ajbio.20140202.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20140202.17},
  abstract = {The barks of thunk of Sclerocarya birrea (ANARCADIACEA) and Khaya senegalensis (ANARCADIACEA) associated with the leaves of Heliotropium indicum (BORRAGINACEA) and Ocimum gratissimum (CESALPINIACEA) usually constitutes a traditional remedy use in Côte d’Ivoire for the treatment of diabetes. This remedy is use according administration a small dose to 35mg/kg. For that reason, each healing plant above was studied to estimate their real effect on the glycaemia of hyperglycemic rats the rats were submitted at oral load of glucose (4g/kg) after received only dose of plant extract. The result showed that, rats whose administrated the aqueous extract of Scleroracaryo birrea, Khaya senegalensis and the aqueous extract of Khaya senegalensis had significant antihypergliycemic effects respectively 30% and 20% (p<0,05 ; n= 8) after 2 hours. These reductions of blood glucose reached 40% and 26% at the 4 hour. The aqueous extract of Ocimum gratissimum didn’t show a significant effect on the glucose blood of the rats, the decrease was 4,5% (p<0,05; n= 8). Concerning the aqueous extract of Heliotropium indicum, we noticed no antihyperglycemic effect on the blood of the rats tested. The phytochemical analysis revealed the presence of alkaloids, coumarins and tannins to Sclerocarya birrea. Khaya senegalensis contained alkaloids and coumarins and polyphenols to Heliotropium indicum. The aqueous extract of Ocimum gratissimum contained flavonoid and tannins. Conclusion: The antihyperglycemic effect of the traditional preparation could be due of antidiabetic activities of Sclerocarya birrea and Khaya senegalensis. However, the aqueous of Heliotroppium indicum and Ocimum gratissimum hadn’t antidiabetic effect so, its can be considered as additives in this traditional preparation. Others detailed investigations are in progress to isolate active ingredient and to determine their mechanism.},
 year = {2014}
}

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TY - JOUR
T1 - Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar
AU - Monteomo Gnate François
AU - Tehoua L.
AU - Ouattara H.
AU - Yapi A.
Y1 - 2014/04/10
PY - 2014
N1 - https://doi.org/10.11648/j.ajbio.20140202.17
DO - 10.11648/j.ajbio.20140202.17
T2 - American Journal of BioScience
JF - American Journal of BioScience
JO - American Journal of BioScience
SP - 60
EP - 63
PB - Science Publishing Group
SN - 2330-0167
UR - https://doi.org/10.11648/j.ajbio.20140202.17
AB - The barks of thunk of Sclerocarya birrea (ANARCADIACEA) and Khaya senegalensis (ANARCADIACEA) associated with the leaves of Heliotropium indicum (BORRAGINACEA) and Ocimum gratissimum (CESALPINIACEA) usually constitutes a traditional remedy use in Côte d’Ivoire for the treatment of diabetes. This remedy is use according administration a small dose to 35mg/kg. For that reason, each healing plant above was studied to estimate their real effect on the glycaemia of hyperglycemic rats the rats were submitted at oral load of glucose (4g/kg) after received only dose of plant extract. The result showed that, rats whose administrated the aqueous extract of Scleroracaryo birrea, Khaya senegalensis and the aqueous extract of Khaya senegalensis had significant antihypergliycemic effects respectively 30% and 20% (p<0,05 ; n= 8) after 2 hours. These reductions of blood glucose reached 40% and 26% at the 4 hour. The aqueous extract of Ocimum gratissimum didn’t show a significant effect on the glucose blood of the rats, the decrease was 4,5% (p<0,05; n= 8). Concerning the aqueous extract of Heliotropium indicum, we noticed no antihyperglycemic effect on the blood of the rats tested. The phytochemical analysis revealed the presence of alkaloids, coumarins and tannins to Sclerocarya birrea. Khaya senegalensis contained alkaloids and coumarins and polyphenols to Heliotropium indicum. The aqueous extract of Ocimum gratissimum contained flavonoid and tannins. Conclusion: The antihyperglycemic effect of the traditional preparation could be due of antidiabetic activities of Sclerocarya birrea and Khaya senegalensis. However, the aqueous of Heliotroppium indicum and Ocimum gratissimum hadn’t antidiabetic effect so, its can be considered as additives in this traditional preparation. Others detailed investigations are in progress to isolate active ingredient and to determine their mechanism.
VL - 2
IS - 2
ER -

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Author Information

Monteomo Gnate François
Tehoua L.

Laboratory of Nutrition and Pharmacology - UFR Biological Sciences-University Péléforo Gbon Coulibaly, Korhogo, C?te d’Ivoire
Ouattara H.

Laboratory of Nutrition and Pharmacology - UFR Biological Sciences-University Péléforo Gbon Coulibaly, Korhogo, C?te d’Ivoire
Yapi A.

Laboratory of Animal Biology - UFR Biosciences- University Félix Houphou?t-Boigny, Abidjan, C?te d’Ivoire

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Monteomo Gnate François, Tehoua L., Ouattara H., Yapi A. (2014). Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar. American Journal of BioScience, 2(2), 60-63. https://doi.org/10.11648/j.ajbio.20140202.17

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Monteomo Gnate François; Tehoua L.; Ouattara H.; Yapi A. Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar. Am. J. BioScience 2014, 2(2), 60-63. doi: 10.11648/j.ajbio.20140202.17

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Monteomo Gnate François, Tehoua L., Ouattara H., Yapi A. Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar. Am J BioScience. 2014;2(2):60-63. doi: 10.11648/j.ajbio.20140202.17

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@article{10.11648/j.ajbio.20140202.17,
  author = {Monteomo Gnate François and Tehoua L. and Ouattara H. and Yapi A.},
  title = {Comparative of the Antihyperglycemic Activity of Sclerocarya Birrea, Khaya Senegalensis, Heliotropium Indicum and Ocimum Gratissimum to Rats Wistar},
  journal = {American Journal of BioScience},
  volume = {2},
  number = {2},
  pages = {60-63},
  doi = {10.11648/j.ajbio.20140202.17},
  url = {https://doi.org/10.11648/j.ajbio.20140202.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20140202.17},
  abstract = {The barks of thunk of Sclerocarya birrea (ANARCADIACEA) and Khaya senegalensis (ANARCADIACEA) associated with the leaves of Heliotropium indicum (BORRAGINACEA) and Ocimum gratissimum (CESALPINIACEA) usually constitutes a traditional remedy use in Côte d’Ivoire for the treatment of diabetes. This remedy is use according administration a small dose to 35mg/kg. For that reason, each healing plant above was studied to estimate their real effect on the glycaemia of hyperglycemic rats the rats were submitted at oral load of glucose (4g/kg) after received only dose of plant extract. The result showed that, rats whose administrated the aqueous extract of Scleroracaryo birrea, Khaya senegalensis and the aqueous extract of Khaya senegalensis had significant antihypergliycemic effects respectively 30% and 20% (p<0,05 ; n= 8) after 2 hours. These reductions of blood glucose reached 40% and 26% at the 4 hour. The aqueous extract of Ocimum gratissimum didn’t show a significant effect on the glucose blood of the rats, the decrease was 4,5% (p<0,05; n= 8). Concerning the aqueous extract of Heliotropium indicum, we noticed no antihyperglycemic effect on the blood of the rats tested. The phytochemical analysis revealed the presence of alkaloids, coumarins and tannins to Sclerocarya birrea. Khaya senegalensis contained alkaloids and coumarins and polyphenols to Heliotropium indicum. The aqueous extract of Ocimum gratissimum contained flavonoid and tannins. Conclusion: The antihyperglycemic effect of the traditional preparation could be due of antidiabetic activities of Sclerocarya birrea and Khaya senegalensis. However, the aqueous of Heliotroppium indicum and Ocimum gratissimum hadn’t antidiabetic effect so, its can be considered as additives in this traditional preparation. Others detailed investigations are in progress to isolate active ingredient and to determine their mechanism.},
 year = {2014}
}

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