Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes

Misbah ur Rehman; Muhammad Imran; Muhammad Arif

doi:doi:10.11648/j.ajac.20130104.13

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Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes

Misbah ur Rehman, Muhammad Imran, Muhammad Arif

Published in American Journal of Applied Chemistry (Volume 1, Issue 4)

Received: 26 October 2013 Published: 10 November 2013

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Abstract

A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.

Published in	American Journal of Applied Chemistry (Volume 1, Issue 4)
DOI	10.11648/j.ajac.20130104.13
Page(s)	59-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Schiff-bases, Amino Acid, Antibacterial, Antifungal, Cytotoxicity

References

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Misbah ur Rehman, Muhammad Imran, Muhammad Arif. (2013). Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes. American Journal of Applied Chemistry, 1(4), 59-66. https://doi.org/10.11648/j.ajac.20130104.13

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ACS Style

Misbah ur Rehman; Muhammad Imran; Muhammad Arif. Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes. Am. J. Appl. Chem. 2013, 1(4), 59-66. doi: 10.11648/j.ajac.20130104.13

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AMA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif. Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes. Am J Appl Chem. 2013;1(4):59-66. doi: 10.11648/j.ajac.20130104.13

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@article{10.11648/j.ajac.20130104.13,
  author = {Misbah ur Rehman and Muhammad Imran and Muhammad Arif},
  title = {Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes},
  journal = {American Journal of Applied Chemistry},
  volume = {1},
  number = {4},
  pages = {59-66},
  doi = {10.11648/j.ajac.20130104.13},
  url = {https://doi.org/10.11648/j.ajac.20130104.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20130104.13},
  abstract = {A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.},
 year = {2013}
}

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TY  - JOUR
T1  - Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes
AU  - Misbah ur Rehman
AU  - Muhammad Imran
AU  - Muhammad Arif
Y1  - 2013/11/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajac.20130104.13
DO  - 10.11648/j.ajac.20130104.13
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 59
EP  - 66
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20130104.13
AB  - A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.
VL  - 1
IS  - 4
ER  -

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Author Information

Misbah ur Rehman

Institute of Chemical Science, Gomal University, D.I. Khan, KPK, Pakistan
Muhammad Imran

Institute of Chemical Science, Bahauddin Zakariya University, Multan, Pakistan
Muhammad Arif

Institute of Chemical Science, Bahauddin Zakariya University, Multan, Pakistan

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APA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif. (2013). Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes. American Journal of Applied Chemistry, 1(4), 59-66. https://doi.org/10.11648/j.ajac.20130104.13

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ACS Style

Misbah ur Rehman; Muhammad Imran; Muhammad Arif. Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes. Am. J. Appl. Chem. 2013, 1(4), 59-66. doi: 10.11648/j.ajac.20130104.13

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AMA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif. Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes. Am J Appl Chem. 2013;1(4):59-66. doi: 10.11648/j.ajac.20130104.13

Copy | Download

@article{10.11648/j.ajac.20130104.13,
  author = {Misbah ur Rehman and Muhammad Imran and Muhammad Arif},
  title = {Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes},
  journal = {American Journal of Applied Chemistry},
  volume = {1},
  number = {4},
  pages = {59-66},
  doi = {10.11648/j.ajac.20130104.13},
  url = {https://doi.org/10.11648/j.ajac.20130104.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20130104.13},
  abstract = {A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Characterization and in Vitro Antimicrobial Studies of Schiff-Bases Derived from Acetylacetone and Amino Acids and their Oxovanadium(IV) Complexes
AU  - Misbah ur Rehman
AU  - Muhammad Imran
AU  - Muhammad Arif
Y1  - 2013/11/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajac.20130104.13
DO  - 10.11648/j.ajac.20130104.13
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 59
EP  - 66
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20130104.13
AB  - A series of novel amino acid derived Schiff-bases and their Oxovanadium(IV) complexes were synthesized and well characterized by elemental analyses, spectral studies, conductivity and magnetic measurements. Physical and analytical data suggest that the Schiff bases act as tridentate ligands towards metal ion via azomethine-N, deprotonated-O of carboxylic group and enolic-O group of acetylacetone. All the complexes have lower molar conductance values, indicating their non-electrolytic nature. The synthesized ligands, along with their metal complexes were screened for their in-vitro antibacterial activity against two Gram-negative (Escherichia coli, Salmonella typhi) and two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, and Candida glaberata species. The results of these studies revealed that all the compounds and their metal complexes showed significant antibacterial and antifungal potency. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.
VL  - 1
IS  - 4
ER  -

Copy | Download